b'The History of AspirinNathan HartSponsor:Dr. Thomas ManningThe story of aspirin begins over three thousand years ago in ancient Sumer and Egypt where medicines derived from willow trees were used to treat fever and pain. However, the medicine known today as aspirin had its start in the late 1700s as an early fever cure. Later in the nineteenth century, organic chemists worked to synthesize, and isolate compounds related to aspirin including salicin and salicylic acid. During the late nineteenth century, chemists discovered a more effective way to synthesize acetylsalicylic acid, the active ingredient in aspirin, and the compound was later put through clinical trials, proving to be an effective antipyretic and analgesic. The name chosen for this drug was aspirin, and by 1950 it had become the worlds most popular painkiller. Despite its initial popularity, aspirins use declined after the development of drugs acetaminophen and ibuprofen. However, because of research exploring aspirins efficacy as an anti-clotting agent as well as the discovery of the basic mechanism of aspirins effects on the body, the use of aspirin was revitalized as indicated by a large increase in sales in the later decades of the twentieth century. Now, aspirin is regarded as a modern preventative treatment for heart attacks and strokes.Inhalation Studies Using an electronic vaporizationInvolving a Novel Cancer drug Kayla Mills and Khyati Patel, Chemistry Department Sponsors: Dr. James Nienow, VSU Department of Biology,Dr. Thomas Manning, VSU Department of ChemistryDr. Dennis Phillips, UGA Mass Spec Lab & Dr. Greg Wylie, Texas A&M NMR Lab An iron-copper medical complex was developed at VSU as a new type of cancer drug. It is based on using the metals, which cancer cells use in higher quantities compared to healthy cells, as a method to accelerate the uptake of the drug in the cancer cell. This complex was accepted into the National Cancer Institute 60 cell line panel for in vitro testing against nine types of cancer. It progressed through 3 levels of evaluation. This poster will outline some experiments that are aimed at evaluating if the complex can be administrated by electronic vaporization as a method to treat lung cancer or leukemia. The electronic technique involves rapidly heating the sample that is dissolved in an alcohol to form nanodroplets, which are needed to penetrate deep within a patients lungs. The ability to permeate lung alveoli and enter serum is critical for treating leukemia. 24'