b'An Economical Synthesis Route in the Ocean for the Marine Natural Product, BryostatinThomas J. Falkenhausen, Matt L. Cowan and Michael L. TidwellSponsor: Dr. Thomas Manning, Department of ChemistryBryostatin is a marine natural product found in minute amounts in nature. Cost 17 million USD/gram, this molecule targets latent HIV reservoirs, has potential for slowing the progression of Alzheimers, and demonstrates strong anti-cancer properties. We have developed an economical synthesis of Bryostatin through the creation of a bioreactor that cultivates a symbiotic bacterium which lives on the bryosome B. Nerintina. This bioreactor is comprised of inexpensive organic materials providing essential nutrients which promotes the growth of the bacterium. Our bioreactor was deployed off the Gulf Coast for a short period to attract our symbiotic bacterium. This bioreactor was returned to the lab where it was monitored weekly for 2 months with sample extraction every other day. Each sample was labeled and stored in cold storage to prevent the degradation of Bryostatin. After our collection period, we ran each sample through a UV Spectrometer to determine the possible presence of Bryostatin. Promising samples were, then, run through a liquid chromatography mass spectrometer to determine the different types of Bryostatin present.Top 50 Essential Medicines for NorwayRachael C. DavisSponsor: Dr. Thomas Manning, Department of ChemistryNorway is found in the arctic circle. We have analyzed at the country of Norway with a focus on the city Ringebu and decided based on common causes of death and disease, which drugs and groups of drugs are necessary. We initially decided on five groups that would not be used in Norway, then ten groups that would be absolutely necessary. This allowed us to further narrow our list to twenty total drugs that is needed to maintain a healthy population in Ringebu, Norway. Top Diseases in Norway include Isochemic Heart, Disease, AIDS, Alzheimers, Cerebrovascular, COPD, Lung Cancer, Measles, and Leighs Disease.27'