b'ChemistryA Biodegradable Drug Delivery Composition, Treating Tuberculosis with a Bioactive Composition Delivered with an InhalerYalanda Gordon and Torien BeardSponsor: Dr. Thomas Manning, Department of ChemistryWe have developed a biodegradable drug delivery composition that can be utilized as a single insert or a dust composted of nanoparticles. This size and shape flexibility allow us to adjust for a specific disease at a specific stage. Because it is biodegradable it does not need to be removed. The composition can be used for different diseases, such as cervical cancer, drug resistant tuberculosis, malaria and Alzheimers disease. Our implants repurpose existing drugs by using bioactive species that are designed to provide additional toxicity, accelerate cellular processes to increase the drug uptake rate, or to defeat resistance mechanisms. For Tb this might translate into sticking with drugs that are well known by the medical community and economical. For Tb we have designed an implant that has one or two antibiotics and a dozen other active ingredients. We have a published several papers on this concept and received a United States patent on one form of the concept working against drug resistant tuberculosis. This published work is not our final product but a starting point and the initial successful effort where we defined our novel approach. This talk will blend our lab-based research with some political, business and intellectual property aspects of the project.22'