The Science Seminar Series: October 23, 2008

FLUORESCENT HETERODITOPIC LIGANDS FOR ZINC ION.

Dr. Lei Zhu

Department of Chemistry and Biochemistry

Florida State University

Place: Powell Hall
Time: 4:00 -5:00pm

Abstract:

The design, preparation, and studies of fluorescent heteroditopic ligands for zinc ion will be presented. Three coordination states (non-, mono-, and di-coordinated) of such a ligand were successfully translated into three fluorescence states (non-fluorescent, fluorescent at one wavelength, and fluorescent at another wavelength, see Figure) through rational design. The mechanistic insight of the coordination-driven photophysical processes uncovered in this unique class of molecules was gained. The applications of these molecules in quantification of zinc ion over relatively large concentration ranges will be described.

References:

1. Zhang, L.; Clark, R. J.; Zhu, L. A Heteroditopic Fluoroionophoric Platform for Constructing Fluorescent Probes with Large Dynamic Ranges for Zinc Ions. Chem. Eur. J. 2008, 14, 2894-2903.

2. Zhang, L.; Whitfield, W. A.; Zhu, L. Unimolecular Binary Half-Adders with Orthogonal Chemical Inputs. Chem. Commun. 2008, 1880-1882.