The Science Seminar Series: February 28, 2008 4pm

Cellular Architecture in a Minimal Microbe: the Simple Life?

Dr. Duncan C. Krause, University of Georgia

Hosting Dept: Biology

Powell Hall

Time: 4:00 - 5:00pm

Abstract

Mycoplasmas are considered to be among the smallest and simplest free-living microorganisms, having minimal genomes, very limited biosynthetic capabilities, and few or no typical mechanisms for regulating gene expression. This minimal nature has contributed to the popularity of mycoplasmas as models for cell and molecular biology, first in membrane structure (since they have no cell wall), later in genome sequencing and proteomic analysis, and more recently in the highly publicized studies by the Venter Institute in synthetic biology- engineering complete cells. And yet mycoplasmas are both fascinating and significant in their own right as major pathogens in humans, other vertebrates, invertebrates, and plants. Some species, including Mycoplasma pneumoniae, are not as simple as they might first seem. The leading cause of pneumonia in older children and young adults, M. pneumoniae possesses a remarkably complex terminal organelle that functions in adherence to host cells, gliding motility, and cell division. We will explore the current understanding of the structure and function of this terminal organelle.